In this technique sperm that have been washed and concentrated are placed directly in your uterus around the time your ovary releases one or more eggs to be fertilized. Unexplained infertility, irregular cycles, uncertain ovulation, and moderate impaired semen quality indicate treatment with insemination of semen directly to the uterine cavity. IUI-D is for use of semen from the donor in contrast to IUI-H where semen from the partner is used.